Lu Zhongding, Ma Kuirong, Sun Yanzhu (Department of Endocrinology, Institute of Zoology, Academia Sinica)
He Bailin, Wang Yingyun, Li Tongying, Wu Xiuying (General Hospital of PLA)
I. EFFECT OF ASPIRIN ON ELECTROACUPUNCTURE ANALGESIA OF HUMAN SKIN
The effect of aspirin (an cialis of prostaglandin biosythesis) on the electro-acupuncture analgesia of human skin was observed. Twenty six healthy volunteers were divided into three groups:
(I) The aspirin group (10 persons);
(II) The vehicleselectro-acupuncture group (24 persons);
(III) The aspirinelectro-acupuncture group (The same 24 persons as in group II, with group II as control, tests were made in either group alternately once a week).
The thresholds of pain and pain tolerance were measured on the skin with square wave electric stimulus given at the point in the upper 1/3 of the line between xiphoid and umbilicus. Electro-acupuncture (continuous electric pulses with a frequency of 15Hz) was given to Zusanli point on both sides.
The results show that 1.5g aspirin alone does not raise the pain threshold and pain tolerance threshold within 60 min. after its oral administration, but it significantly enhances the effect of electro-acupuncture analgesia which is accompanied by a prolonged after-effect (P<0.01). The differences in pain tolerance threshold between groups III and II are highly significant (P<0.001) at the 30th min. of recovery (i.e. 120 min. after administration of the aspirin).
II. PRELIMINARY STUDY IN THE EFFECT OF ASPIRIN ON ELECTRO-ACUPUNCTURE ANESTHESIA
In order to investigate the effect of aspirin, an inhibitor of prostaglandin biosythesis, on acupuncture anesthesia, observations were carried out on patients operated upon with tubal ligation and several other operations. Seven hundreds and forty cases were divided into two groups:
(I) The aspirinelectro-acupuncture group (387 cases);
(II) The vehicleselectro-acupuncture group (353 cases).
Clinical results show that 1.5 g aspirin given to the patients 60 min. before operation (i. e. 20 min. before electro-acupuncture) raises the effectiveness of electro-acupuncture anaesthesia significantly (P<0.001)
The above results are interesting in view of the facts that increase in pain tolerance threshold is characteristic of acupuncture anesthesia and the peripheral analgesic activity of aspirin-like drugs may be explained in term of the removal of the pain sensitizing activity of the endogenous PGs released near the afferent nerve endings. It is thus suggested that PGs (or its precursor) are likely to be one of the humoral factor involved in the regulation of acupuncture analgesia under the integration of the central nervous system.
He Bailin, Wang Yingyun, Li Tongying, Wu Xiuying (General Hospital of PLA)
I. EFFECT OF ASPIRIN ON ELECTROACUPUNCTURE ANALGESIA OF HUMAN SKIN
The effect of aspirin (an cialis of prostaglandin biosythesis) on the electro-acupuncture analgesia of human skin was observed. Twenty six healthy volunteers were divided into three groups:
(I) The aspirin group (10 persons);
(II) The vehicleselectro-acupuncture group (24 persons);
(III) The aspirinelectro-acupuncture group (The same 24 persons as in group II, with group II as control, tests were made in either group alternately once a week).
The thresholds of pain and pain tolerance were measured on the skin with square wave electric stimulus given at the point in the upper 1/3 of the line between xiphoid and umbilicus. Electro-acupuncture (continuous electric pulses with a frequency of 15Hz) was given to Zusanli point on both sides.
The results show that 1.5g aspirin alone does not raise the pain threshold and pain tolerance threshold within 60 min. after its oral administration, but it significantly enhances the effect of electro-acupuncture analgesia which is accompanied by a prolonged after-effect (P<0.01). The differences in pain tolerance threshold between groups III and II are highly significant (P<0.001) at the 30th min. of recovery (i.e. 120 min. after administration of the aspirin).
II. PRELIMINARY STUDY IN THE EFFECT OF ASPIRIN ON ELECTRO-ACUPUNCTURE ANESTHESIA
In order to investigate the effect of aspirin, an inhibitor of prostaglandin biosythesis, on acupuncture anesthesia, observations were carried out on patients operated upon with tubal ligation and several other operations. Seven hundreds and forty cases were divided into two groups:
(I) The aspirinelectro-acupuncture group (387 cases);
(II) The vehicleselectro-acupuncture group (353 cases).
Clinical results show that 1.5 g aspirin given to the patients 60 min. before operation (i. e. 20 min. before electro-acupuncture) raises the effectiveness of electro-acupuncture anaesthesia significantly (P<0.001)
The above results are interesting in view of the facts that increase in pain tolerance threshold is characteristic of acupuncture anesthesia and the peripheral analgesic activity of aspirin-like drugs may be explained in term of the removal of the pain sensitizing activity of the endogenous PGs released near the afferent nerve endings. It is thus suggested that PGs (or its precursor) are likely to be one of the humoral factor involved in the regulation of acupuncture analgesia under the integration of the central nervous system.
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